Introduction of JWH-018 Powder

JWH-018 Powder is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with some selectivity for CB₂. It produces effects in animals similar to those of tetrahydrocannabinol, a cannabinoid naturally present in cannabis, leading to its use as synthetic cannabinoid products that, in some countries, are sold legally as “incense blends”.

JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO  or AM-678)  is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB 1 and CB 2 cannabinoid receptors, with some selectivity for CB 2. JWH-018 powder as it was commonly sold online.

Routes of, administration

By mouth, inhalation.

JWH-018 Powder Legal status

AU: S9 (Prohibited), CA: Schedule II, In general uncontrolled could be illegal to sell for human consumption or theSet product image analogue acts in several countries, DE: Anlage II (Prohibited), UK: Class B, US: Schedule I, UN: Psychotropic Schedule II

CAS Number:

209414-07-3 N

Whats is JWH-018 powder?

JWH-018 powder is a synthetic cannabinoid that mimics the effects of THC, the active component in marijuana. It is often used in products marketed as “spice” or “K2” and can be smoked or ingested, but it may cause severe side effects and is illegal in many places.

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Exploring the Effects of JWH-018 Powder

A 20-year-old man with a history of smoking an herbal mixture called “Spice Gold,” which typically contains CP-47,497-C8 and JWH-018, experienced withdrawal phenomena and a dependence syndrome after chronic consumption. He had been smoking the product daily for 8 months as the only relief from his internal unrest and nervousness. The patient found Spice to be relaxing and sedative, with psychoactive effects very similar to those of cannabis. After experiencing a similar syndrome during a period of abstinence due to a short supply, the patient voluntarily entered the hospital and requested medical treatment for detoxification of Spice. The first symptoms observed by doctors were internal unrest and profuse sweating, followed by drug craving, nocturnal nightmares, tremors, and headaches. Other physical withdrawal symptoms included palpitations, nausea and vomiting, which were similar to those described during cannabis withdrawal.

The diagnosis of dependency was confirmed by the development of drug tolerance. The patient had to rapidly increase his dose from 1 to 3 g/day, felt a continuous strong desire for the drug, and had a persistent urge to consume it despite adverse consequences. Overall, this case highlights the potential for withdrawal and dependence associated with chronic consumption of Spice Gold, containing CP-47,497-C8 and JWH-018, and the need for greater awareness of the risks associated with these types of herbal blends.

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